Pharmacokinetics of methimazole in normal subjects and hyperthyroid patients.
نویسندگان
چکیده
منابع مشابه
Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies
Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history di...
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Plasma concentrations of methimazole, a metabolite of carbimazole, in hyperthyroid patients.
1 Carbimazole was administered to nine hyperthyroid patients, and blood samples were taken at various time intervals for analysis of carbimazole, and its metabolite methimazole.2 A technique was developed for the measurement of methimazole in serum using a High-Pressure Liquid Chromatograph, which could detect nanogram quantities of this metabolite.3 After a single oral dose, the patients' bloo...
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ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1986
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.33.605